Recombinant Human TNF-alpha Protein (GMP Grade)
GMP級(jí)重組人腫瘤壞死因子-alpha蛋白
目錄號(hào)： PM116-01
單 價(jià)：￥440
產(chǎn)品詳情介紹
腫瘤壞死因子（tumor necrosis factor，TNF） ，主要由活化的單核/巨噬細(xì)胞產(chǎn)生，能殺傷和抑制腫瘤細(xì)胞，促進(jìn)中性粒細(xì)胞吞噬，抗感染，引起發(fā)熱，誘導(dǎo)肝細(xì)胞急性期蛋白合成，促進(jìn)髓樣白血病細(xì)胞向巨噬細(xì)胞分化，促進(jìn)細(xì)胞增殖和分化，是重要的炎癥因子，并參與某些自身免疫病的病理?yè)p傷[1-3]。根據(jù)其來(lái)源和結(jié)構(gòu)不同分為兩種類(lèi)型，即TNF-α和TNF-β。TNF-α前體由233個(gè)氨基酸組成，其中包含由76個(gè)氨基酸殘基組成的信號(hào)肽，在TNF轉(zhuǎn)化酶TACE的作用下，切除信號(hào)肽，形成成熟的157個(gè)氨基酸殘基的TNF-α[4-5]。
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[2] Ho YP, Chiu CT, Sheen IS, Tseng SC, Lai PC, Ho SY, Chen WT, Lin TN, Lin CY. Tumor necrosis factor-α and interleukin-10 contribute to immunoparalysis in patients with acute pancreatitis. Hum Immunol. 2011 Jan;72(1):18-23.
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[4] Hayden MS, Ghosh S. Regulation of NF-κB by TNF family cytokines. Semin Immunol. 2014, 26(3):253-266.
[5] Kwon YW, Heo SC, Jeong GO, Yoon JW, Mo WM, Lee MJ, Jang IH, Kwon SM, Lee JS, Kim JH. Tumor necrosis factor-α-activated mesenchymal stem cells promote endothelial progenitor cell homing and angiogenesis. Biochim Biophys Acta. 2013, 1832(12):2136-2144.
