產(chǎn)品詳情介紹
腫瘤壞死因子（tumor necrosis factor，TNF） ，主要由活化的單核/巨噬細(xì)胞產(chǎn)生，能殺傷和抑制腫瘤細(xì)胞，促進(jìn)中性粒細(xì)胞吞噬，抗感染，引起發(fā)熱，誘導(dǎo)肝細(xì)胞急性期蛋白合成，促進(jìn)髓樣白血病細(xì)胞向巨噬細(xì)胞分化，促進(jìn)細(xì)胞增殖和分化，是重要的炎癥因子，并參與某些自身免疫病的病理損傷[1-3]。根據(jù)其來源和結(jié)構(gòu)不同分為兩種類型，即TNF-α和TNF-β。TNF-α前體由233個氨基酸組成，其中包含由76個氨基酸殘基組成的信號肽，在TNF轉(zhuǎn)化酶TACE的作用下，切除信號肽，形成成熟的157個氨基酸殘基的TNF-α[4-5]。
[1] Bishehsari F, Sharma A, Stello K, Toth C, O'Connell MR, Evans AC, LaRusch J, Muddana V, Papachristou GI, Whitcomb DC. TNF-alpha gene (TNFA) variants increase risk for multi-organ dysfunction syndrome (MODS) in acute pancreatitis. Pancreatology. 2012, 12(2):113-118.
[2] Ho YP, Chiu CT, Sheen IS, Tseng SC, Lai PC, Ho SY, Chen WT, Lin TN, Lin CY. Tumor necrosis factor-α and interleukin-10 contribute to immunoparalysis in patients with acute pancreatitis. Hum Immunol. 2011 Jan;72(1):18-23.
[3] Eyerich S, Wagener J, Wenzel V, Scarponi C, Pennino D, Albanesi C, Schaller M, Behrendt H, Ring J, Schmidt-Weber CB, Cavani A, Mempel M, Traidl-Hoffmann C, Eyerich K. IL-22 and TNF-α represent a key cytokine combination for epidermal integrity during infection with Candida albicans. Eur J Immunol. 2011, 41(7):1894-1901.
[4] Hayden MS, Ghosh S. Regulation of NF-κB by TNF family cytokines. Semin Immunol. 2014, 26(3):253-266.
[5] Kwon YW, Heo SC, Jeong GO, Yoon JW, Mo WM, Lee MJ, Jang IH, Kwon SM, Lee JS, Kim JH. Tumor necrosis factor-α-activated mesenchymal stem cells promote endothelial progenitor cell homing and angiogenesis. Biochim Biophys Acta. 2013, 1832(12):2136-2144.
