產(chǎn)品詳情介紹
干細(xì)胞因子（Stem cell factor, SCF），也稱為KIT配體，是一種結(jié)合酪氨酸激酶受體（c-kit）的細(xì)胞因子。SCF也被稱為“c-kit配體”[1-2]。SCF是一種對造血干細(xì)胞和其他造血祖細(xì)胞的存活、增殖和分化很重要的生長因子。其作用之一是將紅細(xì)胞系列中最早的紅細(xì)胞前體BFU-E（突發(fā)形成單位紅細(xì)胞）細(xì)胞轉(zhuǎn)變?yōu)镃FU-E（集落形成單位紅細(xì)胞）[3]。重組SCF可以與G-CSF聯(lián)合使用，提高外周血中CD34+細(xì)胞的濃度，動員外周血祖細(xì)胞（PBPC），快速恢復(fù)癌癥患者的骨髓造血功能。在自體造血干細(xì)胞移植中，SCF的使用可以增加動員到外周血的造血干細(xì)胞數(shù)量，有助于收集足夠數(shù)量的干細(xì)胞以進(jìn)行移植[4]。
[1] Zsebo KM, Williams DA, Geissler EN, Broudy VC, Martin FH, Atkins HL, Hsu RY, Birkett NC, Okino KH, Murdock DC, et al. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor[J]. Cell, 1990, 63(1):213-224.
[2] Williams DE, Lyman SD. Characterization of the gene-product of the Steel locus. Prog Growth Factor Res, 1991,3(4):235-242.
[3] Bazan JF. Genetic and structural homology of stem cell factor and macrophage colony-stimulating factor. Cell, 1991, 65(1):9-10.
[4] da Silva, M., Pimentel, P., Carvalhais, A. et al. Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collection. Bone Marrow Transplant, 2004, 34, 683–691.
