產(chǎn)品詳情介紹
白介素-2（Interleukin-2，IL-2）是第一個(gè)被克隆的白介素因子，又稱T細(xì)胞生長(zhǎng)因子，與IL-2受體（IL-2R）結(jié)合可刺激T細(xì)胞進(jìn)入細(xì)胞分裂周期，使T細(xì)胞在體外長(zhǎng)期存活[1]。除T細(xì)胞外，IL-2也可通過(guò)與NK細(xì)胞表面的IL-2R結(jié)合促進(jìn)NK細(xì)胞的增殖和殺傷活性[2]。IL-2是一個(gè)多效性細(xì)胞因子，還可以促進(jìn)腫瘤浸潤(rùn)淋巴細(xì)胞的增殖、促進(jìn)B細(xì)胞增殖和產(chǎn)生免疫球蛋白、刺激巨噬細(xì)胞提高其吞噬能力[3]。
本產(chǎn)品由134個(gè)氨基酸殘基組成，由CHO細(xì)胞表達(dá)，經(jīng)分離和高度純化后凍干制成。
[1] Malek TR. The Biology of Interleukin-2. Annual Review of Immunology 2008, 26(1):453-479.
[2] Becker PSA, Suck G, Nowakowska P, Ullrich E, Seifried E, Bader P, Tonn T, Seidl C. Selection and expansion of natural killer cells for NK cell-based immunotherapy. Cancer Immunology, Immunotherapy 2016, 65(4):477-484.
[3] Gaffen S, Liu K. Overview of interleukin-2 function, production and clinical applications. Cytokine 2004, 28(3):109-123.
