產(chǎn)品詳情介紹
Thy-1/CD90是一種GPI錨定、受發(fā)育調(diào)控的細(xì)胞表面糖蛋白。它參與多種細(xì)胞類型的細(xì)胞粘附和細(xì)胞通訊，尤其是在免疫和神經(jīng)系統(tǒng)的細(xì)胞中。Thy-1/CD90被廣泛用作造血干細(xì)胞的標(biāo)記物[1]。Thy-1/CD90 mRNA和蛋白表達(dá)下降與上皮性卵巢癌的發(fā)生有關(guān)聯(lián)，表明可能具有潛在的人卵巢癌抑癌基因作用[2]。研究表明，Thy-1/CD90 敲除小鼠會(huì)出現(xiàn)皮膚免疫應(yīng)答受損及視網(wǎng)膜發(fā)育異常[3]。Thy-1/CD90在某些疾病狀態(tài)（如肺纖維化）受表觀遺傳調(diào)節(jié)，或出現(xiàn)失調(diào)，Thy-1/CD90啟動(dòng)子的潛在可逆過度甲基化可能會(huì)為這種疾病提供新的治療選擇[4]。本產(chǎn)品為小鼠抗人Thy-1/CD90單克隆抗體，用于WB方法特異性檢測(cè)人Thy-1/CD90蛋白。
CD系列產(chǎn)品介紹視頻
[1] Majeti R, Park CY, Weissman IL. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood [J]. Cell Stem Cell. 2007, 1(6): 635-45.
[2] Abeysinghe HR, Cao Q, Xu J, et al. THY1 expression is associated with tumor suppression of human ovarian cancer [J]. Cancer Genet Cytogenet. 2003, 143(2): 125-32.
[3] Simon PD, Mcconnell J, Zurakowski D, et al. Thy-1 is critical for normal retinal development [J]. Brain Res Dev Brain Res. 1999, 117(2): 219-23.
[4] Sanders YY, Pardo A, Selman M, et al. Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis [J]. Am J Respir Cell Mol Biol. 2008, 39(5): 610-8.
